Assert the page declares (or does not declare) TYPO3 as its generator: <meta name="generator" content="TYPO3 CMS">, which every TYPO3 front-end page carries unless the site removes it.
Examples
Then the site should be running TYPO3
And the site should be running TYPO3
Then the site should not be running TYPO3
But the site should not be running TYPO3
Then the site should be running TYPO3 CMS
Pattern
Then(/^the site should( not)* be running TYPO3(?: CMS)?$/, …)
Part of @webship-js/typo3-steps (github.com/webship/typo3-steps), a step pack for Webship-js 2.0.x.